What is the mechanism of action of naloxone?

Naloxone works by displacing opioids from their receptors, primarily the mu-opioid receptors in the central nervous system. This action is crucial because naloxone is utilized as an opioid antagonist to reverse the effects of opioid overdose. When administered, naloxone competes with opioids for binding to these receptors and, due to its higher affinity for these sites, can effectively block the action of opioids.

This mechanism is particularly important in emergency situations where an individual has overdosed on opioids, as it can quickly restore normal respiratory function by reversing the respiratory depression caused by opioid agonists. Consequently, the rapid administration of naloxone can be life-saving.

The other options do not accurately represent naloxone's action. Stimulation of opioid receptors and enhancement of opioid effects contradict the role of naloxone as an antagonist. Inhibition of neurotransmitter release is more related to the effects of various opioids rather than the mechanism of action of naloxone itself.