True or false: Patients prescribed immediate-release opioids as their initial prescription are at a higher risk of overdose compared to those prescribed extended-release opioids.

The statement that patients prescribed immediate-release opioids as their initial prescription are at a higher risk of overdose compared to those prescribed extended-release opioids is false. Immediate-release opioids are designed for situational pain relief and their use typically involves a more controlled dosing regimen. Patients often take these medications on an as-needed basis, which can result in lower cumulative exposure to the drug compared to continuous use of extended-release formulations.

Extended-release opioids, on the other hand, provide a continuous release of medication over a longer period. This can lead to higher overall plasma levels of the drug, especially if patients do not have a well-managed pain plan or if they take doses incorrectly. Consequently, patients on extended-release opioids may be at a greater risk for overdose due to the sustained and possibly excessive doses.

In summary, the risk of overdose is not inherently higher for those on immediate-release opioids when compared to extended-release formulations; in fact, immediate-release opioids may offer a lower risk profile in situations where they are used appropriately.